Hamilton High School opened in 1998 with 1,600 students in freshman through junior years, in a still agricultural area on the edge of the city. It was named after the Hamilton family, one of the pioneer families of Chandler, who farmed the land where the school now stands. John Augustus Hamilton was a World War I combat veteran and sheriff of the southeast area of Phoenix. The school's football stadium now stands on what was known for years as Hamilton's Corner, the corner of Arizona Avenue/Arizona State Route 87 and Ocotillo, where the Hamiltons ran a general store.

Most of the school is housed in a two-story enclosed structure, which increases safety and provides protection from the hot weather in summer. Classrooms and primary facilities are located on one of eight main hallways, each of which has its own staircase and which also connect to the library, administrations office, cafeteria, gym, and auditorium. Both the library and the swimming pool are also city facilities.

The campus was originally built to hold 2,600 students; as of 2 October 2017, there are 3,740 enrolled. The auditorium and cafeteria each seat about 600 students, the gym seats about 1,900, and the football stadium seats 10,000. In addition to the swimming pool, the school also has a track, ten tennis courts, two soccer fields, and six fields used for baseball and practice.

A second building accommodating twelve freshman- and sophomore-level classes was completed in September 2014.

Football History

Hamilton High School's football team won Arizona Division 5A State Championships in 2003, 2004, 2006, 2008, 2009, 2010, and 2012 (Division I). Hamilton had a 53-game winning streak until losing to Phoenix Desert Vista at the 5A state championships in November 2011.